好菌,好肠道,大产业
张和平
时长:11:23 分会场:2019中国肠道大会 - 开幕式
张和平
内蒙古农业大学食品科学与工程学院
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医学文化重塑
从肠道微生态重建和肠道领域跨学科发展趋势分析医学文化重塑
樊代明 时长:26:49
Host-microbiome interactions in health and disease
The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant hostmicrobiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, the metabolic syndrome and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, lead to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to development of new microbiome-targeting treatments.
Eran Elinav 时长:24:17
微生物组大数据分析中的生态学原理分析
赵立平 时长:24:03
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