多吃低农药残留的果蔬，或可降低死亡风险
- ①纳入来自3个队列的137,378名女性及23,502名男性，在3,081,360人-年的随访期间，共发生27,026例死亡事件；
- ②相比于每日摄入＜1份的低农药残留果蔬的受试者，每日摄入≥4份的低农药残留果蔬的受试者的死亡风险显著降低36%；
- ③相比于每日摄入＜1份的高农药残留果蔬的受试者，每日摄入≥4份的高农药残留果蔬的受试者的死亡风险无显著变化；
- ④果蔬摄入与心血管疾病死亡风险、癌症死亡风险及呼吸道疾病死亡风险存在与上述相似的关联模式。
主编推荐语
Environment International上发表的一项前瞻性队列研究结果，对超过16万名受试者进行近20年随访后发现，高农药残留的水果蔬菜的摄入量与死亡风险无显著关联，而摄入更多的低农药残留的水果蔬菜与全因死亡风险及疾病特异性死亡风险（包括癌症、心血管疾病、呼吸道疾病）的降低显著相关。
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延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Intake of fruits and vegetables according to pesticide residue status in relation to all-cause and disease-specific mortality: Results from three prospective cohort studies
根据农药残留状态，水果及蔬菜摄入与全因死亡及疾病特异性死亡率相关：来自3项前瞻性队列研究的结果
10.1016/j.envint.2021.107024
2021-12-08, Article
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Abstract:收起
BACKGROUND: Intake of conventionally grown fruits and vegetables (FVs) is an important route of exposure to pesticide residues in the general population. However, whether health risk stemming from exposure to pesticides through diet could offset benefits of consuming FVs is unclear.
OBJECTIVE: We assessed the association of FV intake, classified according to their pesticide residue status, with total and cause-specific mortality.
METHODS: We followed 137,378 women (NHS, 1998-2019, and NHSII, 1999-2019) and 23,502 men (HPFS, 1998-2020) without cardiovascular disease, cancer, or diabetes at baseline. FV intake was assessed using validated food frequency questionnaires and categorized as having high- or low-pesticide-residues using data from the USDA Pesticide Data Program. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for total and cause-specific mortality associated with high- and low-pesticide-residue FV intake.
RESULTS: A total of 27,026 deaths, including 4,318 from CVD and 6,426 from cancer, were documented during 3,081,360 person-years of follow-up. In multivariable-adjusted analyses, participants who consumed ≥4 servings/day of low-pesticide-residue FVs had 36% (95% CI: 32%-41%) lower mortality risk compared to participants who consumed <1 serving/day. The corresponding estimate for high-pesticide residue FV intake was 0.93 (95% CI: 0.81-1.07). This pattern was similar across the three most frequent causes of death (cardiovascular disease, cancer and respiratory diseases).
CONCLUSIONS: High-pesticide-residue FV intake was unrelated whereas low-pesticide residue FV intake was inversely related to all-cause mortality, suggesting that exposure to pesticide residues through diet may offset the beneficial effect of FV intake on mortality.
First Authors:
Helena Sandoval-Insausti
Correspondence Authors:
Helena Sandoval-Insausti,Jorge E Chavarro
All Authors:
Helena Sandoval-Insausti,Yu-Han Chiu,Yi-Xin Wang,Jaime E Hart,Shilpa N Bhupathiraju,Lidia Mínguez-Alarcón,Ming Ding,Walter C Willett,Francine Laden,Jorge E Chavarro
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