Science：少吃延长小鼠寿命，与昼夜节律匹配效果更好
- ①在C57BL/6J雄性小鼠中，研究5种进食和禁食模式的30%热量限制（CR）对寿命和健康的影响，以自由进食为对照；
- ②全天分散进食（无昼夜差异和长期禁食）的CR可延寿10%，进食时间与昼夜节律不匹配（在休息期进食，之后禁食）的CR可延寿20%，而每天仅在活动期（夜间）进食、之后长期禁食的CR可延寿35%；
- ③这些作用与体重无关；
- ④在自由进食的小鼠中，衰老使肝脏的炎症相关基因表达升高、代谢相关基因表达降低，而与昼夜节律匹配的CR能减少这些衰老相关变化。
主编推荐语
热量限制（CR）可延长实验小鼠的寿命。但在CR研究中，小鼠会自发形成给食后2小时内吃完而后22小时禁食的进食时间模式，这使得研究者难以搞清CR延寿的作用究竟是因为减少热量，还是长期禁食，抑或是进食时间。Science最新发表的一项研究，为了回答这一问题，设计了5种CR模式，来研究CR下的每日进食时间（与昼夜节律一致或相反）和禁食期时长对健康的影响。结果表明，与昼夜节律匹配的CR能更好地延长小鼠寿命。这些发现强调了饮食遵循昼夜节律的重要性，也为进一步研究衰老机制提供了新视角。
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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
昼夜节律协调的早开始热量限制促进雄性C57BL/6J小鼠的长寿
10.1126/science.abk0297
2022-05-05, Article
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Caloric restriction (CR) prolongs lifespan, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour-feeding and 22-hour-fasting, raising the question whether calories, fasting, or time of day are causal. We show that 30%-CR is sufficient to extend lifespan 10%; however, a daily fasting interval and circadian-alignment of feeding act together to extend lifespan 35% in male C57BL/6J mice. These effects are independent of body weight. Aging induces widespread increases in gene expression associated with inflammation and decreases in expression of genes encoding components of metabolic pathways in liver from ad lib fed mice. CR at night ameliorates these aging-related changes. Thus, circadian interventions promote longevity and provide a perspective to further explore mechanisms of aging.
First Authors:
Victoria Acosta-Rodríguez
Correspondence Authors:
Carla B Green,Joseph S Takahashi
All Authors:
Victoria Acosta-Rodríguez,Filipa Rijo-Ferreira,Mariko Izumo,Pin Xu,Mary Wight-Carter,Carla B Green,Joseph S Takahashi
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