王刚等:益生菌、生物活性化合物及饮食模式如何影响高尿酸血症(综述)
- ①饮食模式通过调节宿主的嘌呤代谢,或通过调控肠道菌群,分别直接或间接影响高尿酸血症的发生;
- ②地中海饮食与DASH饮食有助于降低血清尿酸浓度,从而预防高尿酸血症;
- ③益生菌可通过吸收嘌呤、恢复失调的肠道菌群、抑制黄嘌呤氧化酶(XO)的活性,从而缓解高尿酸血症;
- ④多酚、多肽和生物碱等多种生物活性化合物可通过调节尿酸盐转运蛋白、阻断XO活性位点、抑制TLR4/NF-κB信号通路、NLRP3信号通路等发挥抗高尿酸血症作用。
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高尿酸血症与高血压、糖尿病、肾衰竭及其它代谢综合征的风险增加相关。江南大学的王刚团队在Critical Reviews in Food Science and Nutrition上发表的一篇综述文章,详细介绍了益生菌、生物活性化合物、饮食模式调节高尿酸血症的效果及作用机制。
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Probiotics, bioactive compounds and dietary patterns for the effective management of hyperuricemia: a review
益生菌、生物活性化合物及饮食模式对高尿酸血症的有效管理:综述
10.1080/10408398.2022.2119934
2022-09-08, Review
Abstract & Authors:展开
Abstract:收起
Hyperuricemia is closely linked with an increased risk of developing hypertension, diabetes, renal failure and other metabolic syndromes. Probiotics, bioactive compounds and dietary patterns are safe cost-efficient ways to control hyperuricemia, whereas comprehensive reviews of their anti-hyperuricemic mechanisms are limited. This review summarizes the roles of probiotics, bioactive compounds and dietary patterns in treating hyperuricemia and critically reviews the possible mechanisms by which these interventions exert their activities. The dietary patterns are closely related to the occurrence of hyperuricemia through the indirect action of gut microbiota or the direct effects of host purine metabolism. The Mediterranean and Dietary Approaches to Stop Hypertension diets help reduce serum uric acid concentrations and thus prevent hyperuricemia. Meanwhile, probiotics alleviate hyperuricemia by ways of absorbing purine, restoring gut microbiota dysbiosis and inhibiting xanthine oxidase (XO) activity. Bioactive compounds such as polyphenols, peptides and alkaloids exert various anti-hyperuricemic effects, by regulating urate transporters, blocking the active sites of XO and inhibiting the toll-like receptor 4/nuclear factor kappa B signaling pathway and NOD-, LRR- and pyrin domain-containing protein 3 signaling pathway. This review will assist people with hyperuricemia to adopt a healthy diet and contribute to the application of natural products with anti-hyperuricemic activity.
First Authors:
Lei Sun
Correspondence Authors:
Gang Wang
All Authors:
Lei Sun,Caixin Ni,Jianxin Zhao,Gang Wang,Wei Chen
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