赵文婧+牟相宇：菌群对抗癌药物的影响（综述）
- ①肠道菌群通过免疫调节、微生物酶降解和药物代谢等机制调节抗癌药物的疗效和毒性及预后；
- ②脆弱拟杆菌、阿克曼氏菌等分别通过免疫调节增强奥沙利铂及免疫检查点抑制剂的药效，而具核梭杆菌等通过其潜在机制降低药效或增加毒性；
- ③改善癌症治疗效果的潜在菌群调节策略包括：粪菌移植、益生菌、噬菌体以及饮食干预等；
- ④目前面临的问题包括人体与动物模型的药效差异、标准流程的建立等，需进一步了解菌群、宿主反应和抗癌药物间的相互作用。
主编推荐语
肠道菌群通过免疫调节和微生物酶降解等机制在调节抗癌药物的功效和毒性方面发挥着关键作用。近日中山大学赵文婧、牟相宇团队在EBioMedicine发表综述，分析了目前关于肠道菌群、宿主反应和抗癌疗（包括细胞毒性化学疗法和靶向疗法）之间的相互作用，提供了几种菌群依赖的调节策略用以改善癌症治疗的效果，并提出了未来的临床和临床前研究所面临的问题。因此，菌群作为癌症治疗精准医学的靶标具有令人兴奋的前景。
关键字
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Effects of microbiota on anticancer drugs: Current knowledge and potential applications
菌群对抗癌药物的影响:当下的知识和潜在的应用
10.1016/j.ebiom.2022.104197
2022-08-04, Review
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Over the last decade, mounting evidence has revealed the key roles of gut microbiota in modulating the efficacy and toxicity of anticancer drugs, via mechanisms such as immunomodulation and microbial enzymatic degradation. As such, human microbiota presents as an exciting prospect for developing biomarkers for predicting treatment outcomes and interventional approaches for improving therapeutic effects. In this review, we analyze the current knowledge of the interplays among gut microorganisms, host responses and anticancer therapies (including cytotoxic chemotherapy and targeted therapy), with an emphasis on the immunomodulation function of microbiota which facilitates the efficacy of immune checkpoint inhibitors. Moreover, we propose several microbiota-modulating strategies including fecal microbiota transplantation and probiotics, which can be pursued to optimize the use and development of anticancer treatments. We anticipate that future clinical and preclinical studies will highlight the significance of human microbiome as a promising target towards precision medicine in cancer therapies. FUNDING: National Key Research and Development Program of China (2020YFA0907800), Shenzhen Science and Technology Innovation Program (KQTD20200820145822023) and National Natural Science Foundation of China (31900056 and 32000096).
First Authors:
Jiayuan Huang,Wenting Liu
Correspondence Authors:
Xiangyu Mou,Wenjing Zhao
All Authors:
Jiayuan Huang,Wenting Liu,Wanying Kang,Yulong He,Ruifu Yang,Xiangyu Mou,Wenjing Zhao
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