口腔菌群与胰腺癌（综述）
- ①较差的口腔健康状况及口腔微生物失调均与胰腺癌的发生发展密切相关；
- ②个体在基因、种族、社会经济状况、抽烟与否及年龄的差异影响其口腔微生物的组成情况；
- ③胰腺与唾液腺有诸多相似点，因此口腔微生物或可反映癌变过程中胰腺的变化情况；
- ④胰腺微生物可能由口腔、肠道或血液微生物定植而来，且口腔致病菌或与胰腺癌有关；
- ⑤慢性炎症是胰腺癌发展中的危险因素；
- ⑥工程化的口腔微生物有望用于胰腺癌的临床治疗，为疾病治疗提供新思路。
主编推荐语
胰腺癌是一种恶性程度高、诊断和治疗都很困难的消化道恶性肿瘤。其发病率、治疗和结果存在个体差异。胰腺癌患者的口腔微生物会发生变化，并且在胰腺肿瘤中发现了口腔中常见的病原菌。但对于胰腺癌患者口腔微生物群如何或为什么不同还有很多未知。发表在Microbiome上的一篇综述总结了口腔健康、口腔菌群和胰腺癌之间的已知联系，讨论了人类多样性如何影响口腔菌群的组成，并探索了人类多样性、口腔菌群和胰腺癌发展相互作用背后的潜在机制，加深了人们对口腔菌群与胰腺癌之间相互作用的理解。
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延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine
精准医疗时代：口腔微生物组、胰腺癌及个体多样性的关系
10.1186/s40168-022-01262-7
2022-06-15, Review
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Abstract:收起
Pancreatic cancer is a deadly disease with limited diagnostic and treatment options. Not all populations are affected equally, as disparities exist in pancreatic cancer prevalence, treatment and outcomes. Recently, next-generation sequencing has facilitated a more comprehensive analysis of the human oral microbiome creating opportunity for its application in precision medicine. Oral microbial shifts occur in patients with pancreatic cancer, which may be appreciated years prior to their diagnosis. In addition, pathogenic bacteria common in the oral cavity have been found within pancreatic tumors. Despite these findings, much remains unknown about how or why the oral microbiome differs in patients with pancreatic cancer. As individuals develop, their oral microbiome reflects both their genotype and environmental influences. Genetics, race/ethnicity, smoking, socioeconomics and age affect the composition of the oral microbiota, which may ultimately play a role in pancreatic carcinogenesis. Multiple mechanisms have been proposed to explain the oral dysbiosis found in patients with pancreatic cancer though they have yet to be confirmed. With a better understanding of the interplay between the oral microbiome and pancreatic cancer, improved diagnostic and therapeutic approaches may be implemented to reduce healthcare disparities.
First Authors:
Kelly M Herremans
Correspondence Authors:
Jose G Trevino
All Authors:
Kelly M Herremans,Andrea N Riner,Miles E Cameron,Kelley L McKinley,Eric W Triplett,Steven J Hughes,Jose G Trevino
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