Nature Reviews:基于肠道菌群的疾病标志物(综述)
  • 炎症性肠病(IBD)和2型糖尿病(T2DM)之间存在一些共性,相关的肠道菌群及宿主处理细菌衍生代谢物的变化,是共同的潜在致病机制;
  • 通过悉生小鼠实验和多组学研究,建立菌群紊乱与IBD或T2DM之间的因果关系;
  • 疾病特生物标志物发现的挑战包括确定变化的因果关系,理解疾病机制中的功能冗余、肠道菌群的地理和种族异质性;
  • 识别疾病生物标志物,需要对特定菌株、其编码基因和代谢产物进行大数据细化、测试和验证。
肠道菌群失调与多种人类疾病有关,包括2型糖尿病(T2DM)和炎症性肠病(IBD)等。Nature Reviews Gastroenterology and Hepatology发表的这篇长综述,以T2DM和IBD为例,介绍了二者在病理和肠道菌群失调方面的共性特征,总结和评估了这两种疾病的肠道菌群相关标志物以及不同研究间的异同,讨论了包括代谢组学在内的菌群相关标志物的发现和应用,及其对研究疾病机理的意义。文章干货很多,值得专业人士学习参考。

Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders



2022-02-21, Review

Abstract & Authors:展开

The intestine harbours a complex array of microorganisms collectively known as the gut microbiota. The past two decades have witnessed increasing interest in studying the gut microbiota in health and disease, largely driven by rapid innovation in high-throughput multi-omics technologies. As a result, microbial dysbiosis has been linked to many human pathologies, including type 2 diabetes mellitus and inflammatory bowel disease. Integrated analyses of multi-omics data, including metagenomics and metabolomics along with measurements of host response and cataloguing of bacterial isolates, have identified many bacteria and bacterial products that are correlated with disease. Nevertheless, insight into the mechanisms through which microbes affect intestinal health requires going beyond correlation to causation. Current understanding of the contribution of the gut microbiota to disease causality remains limited, largely owing to the heterogeneity of microbial community structures, interindividual differences in disease evolution and incomplete understanding of the mechanisms that integrate microbiota-derived signals into host signalling pathways. In this Review, we provide a broad insight into the microbiome signatures linked to inflammatory and metabolic disorders, discuss outstanding challenges in this field and propose applications of multi-omics technologies that could lead to an improved mechanistic understanding of microorganism–host interactions.

First Authors:
Amira Metwaly

Correspondence Authors:
Dirk Haller

All Authors:
Amira Metwaly,Sandra Reitmeier,Dirk Haller