多吃富含镁的食物,或可降低早死和癌症死亡风险
创作:楸楸 审核:aluba 2021年03月28日
  • 纳入19项前瞻性队列研究(共涉及1,168,756名参与者,随访3.5-32年)进行荟萃分析,总结总镁、补充镁和膳食镁摄入量与全因、癌症和心血管疾病(CVD)死亡风险之间的剂量效应关联;
  • 膳食镁的摄入量与全因死亡风险及癌症死亡风险之间呈显著负相关,与CVD死亡风险无显著关联;
  • 补充镁和总镁摄入量与全因、CVD和癌症死亡风险之间均无显著关联;
  • 每天的膳食镁摄入量每增加100mg,全因及癌症死亡风险分别降低6%和5%。
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Advances in Nutrition上发表的一项荟萃分析结果,总结19项前瞻性队列研究(超过110万名参与者)的数据后发现,膳食中的镁摄入量(而非总的镁摄入量或补充镁摄入量)越高,全因死亡风险及癌症死亡风险越低。
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Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies

总镁、膳食镁和补充镁的摄入与全因、心血管和癌症死亡率的风险:前瞻性队列研究的系统综述和剂量效应荟萃分析

10.1093/advances/nmab001

2021-03-03, Review

Abstract & Authors:展开

Abstract:收起
A meta-analysis of prospective studies was conducted to examine the association of total, supplemental, and dietary magnesium intakes with risk of all-cause, cancer, and cardiovascular disease (CVD) mortality and identify the dose–response relations involved in these association. We performed a systematic search of PubMed, Scopus, Google Scholar, and ISI Web of Knowledge up to April 2020. Prospective cohort studies that reported risk estimates for the association between total, supplemental, and dietary magnesium intakes and risk of mortality were included. Random effects models were used. Nineteen publication with a total of 1,168,756 participants were included in the current meta-analysis. In total, 52,378 deaths from all causes, 23,478 from CVD, and 11,408 from cancer were identified during the follow-up period of 3.5 to 32 years. Dietary magnesium intake was associated with a lower risk of all-cause [pooled effect size (ES): 0.87; 95% CI: 0.79, 0.97; P = 0.009; I2 = 70.7%; P < 0.001] and cancer mortality (pooled ES: 0.80; 95% CI: 0.67, 0.97; P = 0.023; I2 = 55.7%; P = 0.027), but not with CVD mortality (pooled ES: 0.93; 95% CI: 0.82, 1.07; P = 0.313; I2 = 72.3%; P < 0.001). For supplemental and total magnesium intakes, we did not find any significant associations with risks of all-cause, CVD, and cancer mortality. However, linear dose–response meta-analysis indicated that each additional intake of 100 mg/d of dietary magnesium was associated with a 6% and 5% reduced risk of all-cause and cancer mortality, respectively. In conclusion, higher intake of dietary magnesium was associated with a reduced risk of all-cause and cancer mortality, but not CVD mortality. Supplemental and total magnesium intakes were not associated with the risk of all-cause, CVD, and cancer mortality. These findings indicate that consumption of magnesium from dietary sources may be beneficial in reducing all-cause and cancer mortality and thus have practical importance for public health.

First Authors:
Amir Bagheri

Correspondence Authors:
Ahmad Esmaillzadeh

All Authors:
Amir Bagheri,Sina Naghshi,Omid Sadeghi,Bagher Larijani,Ahmad Esmaillzadeh

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