郑州大学：外出就餐频率与血尿酸水平及高尿酸血症相关
- ①本横断面研究分析了来自河南农村队列研究的经过食物频率问卷调查的29,597名参与者，其中共有3492人被诊断为高尿酸血症；
- ②在总人群和男性中，外出就餐与较高的血清尿酸（SUA）水平显著相关；
- ③外出就餐≥7次/周相比0次/周的人，总人群和男性的高尿酸血症的多变量校正OR值分别为1.26和1.18，有统计学意义；
- ④外出就餐频率和高尿酸血症呈非线性剂量反应正相关，而BMI在此关联中起部分中介作用，在总人群和男性中分别可解释30.7%和44.8%。
主编推荐语
随着中国老百姓经济水平的提高，更多的人更频繁地走出家门在外就餐享受各种美食，俗话说得好“没有什么是一顿火锅解决不了的，如果有那就是两顿”。但随着外出就餐的增多，可能伴随着一定的健康隐患。近期郑州大学公共卫生学院流行病与卫生统计学系王重建和本校药学院临床药学系李玉倩作为共同通讯作者在European Journal of Nutrition发表的一项研究表明在中国农村地区，尤其是男性，外出就餐与血清尿酸（SUA）水平升高和高尿酸血症风险升高相关，而这一关联部分受BMI所介导。主编友情提醒，其实在外就餐有时是难以避免的，关键是做出较好的食物选择，避免吃的过油过咸和过多。
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Association of eating out frequency and other factors with serum uric acid levels and hyperuricemia in Chinese population
中国人群外出就餐频率等因素与血尿酸水平及高尿酸血症的关系
10.1007/s00394-021-02634-9
2021-07-23, Article
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PURPOSE: A significant shift in meal pattern with frequent eating out was closely associated with multiple chronic outcomes, but with limited evidence on hyperuricemia. We aimed to explore the associations between eating out and serum uric acid (SUA) as well as hyperuricemia.
METHODS: A total of 29,597 participants were recruited from the Henan Rural Cohort Study. A validated food frequency questionnaire (FFQ) was used to collect dietary data, including the frequency of eating out. Linear regression models were used to examine the association of eating-out frequency with SUA and BMI. Logistic regression and restricted cubic spline were performed to assess the association and dose-response relationship between eating-out frequency and hyperuricemia. The mediation effect of BMI between eating out and the risk of hyperuricemia was evaluated.
RESULTS: Eating out was significantly associated with higher SUA levels in the total population and males (P < 0.001). Multivariate-adjusted odds ratios (ORs) with 95% confidence interval (CIs) of hyperuricemia were 1.26 (1.09, 1.46) for the total population and 1.18 (1.00, 1.40) for males (≥ 7 times/week vs 0 time/week). A non-linear positive dose-response relationship between eating-out frequency and hyperuricemia was observed. Furthermore, BMI played a partial mediating role in the relationship between eating out frequency and hyperuricemia, which explained 30.7% in the total population and 44.8% in males.
CONCLUSION: Our findings indicated that eating out was associated with increased SUA levels and elevated hyperuricemia risk in rural China, especially in males. Moreover, the relationship was partly mediated by BMI.
CLINICAL TRIALS: ChiCTR-OOC-15006699 (2015-07-06).
First Authors:
Ningning Cui,Xiaokang Dong
Correspondence Authors:
Chongjian Wang,Yuqian Li
All Authors:
Ningning Cui,Xiaokang Dong,Wei Liao,Yuan Xue,Xiaotian Liu,Xing Li,Jian Hou,Wenqian Huo,Linlin Li,Zhenxing Mao,Chongjian Wang,Yuqian Li
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