王金锋团队:微生物组在改善母婴健康中的应用潜力(综述)
- ①不同身体部位的微生物组可用于妊娠并发症和不良妊娠结局的早期预测、辅助诊断、长期监测和回溯诊断;
- ②母婴营养和健康的精准管理中应将菌群纳入考虑范畴;
- ③由于微生物可从母亲传递给婴儿,母体微生物组或可作为新生儿健康的指标和靶点;
- ④婴儿微生物组可作为其生长发育和营养状况的评估指标,菌群干预或可改善营养不良;
- ⑤菌群可用于指导母婴健康产品的开发(如母婴益生菌/益生元),以及安全性评估和精准应用。
主编推荐语
微生物通常对其宿主(包括母亲和婴儿)的生理和病理状态的转变很敏感。因此,微生物组可能是孕期疾病的一个很好的指标,并有可能用于围产期健康监测。中国农业大学王金锋团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章,阐述了微生物组在母婴健康领域中的应用前景,值得专业人士关注。
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Maternal and infant microbiome: next-generation indicators and targets for inter-generational health and nutrition care
母婴微生物组:代际健康与营养护理的下一代指标和靶点
10.1093/procel/pwad029
05-15, Review
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Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts, including mothers and babies. From this perspective, the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health monitoring. This is embodied in the application of microbiome from multi body sites for auxiliary diagnosis, early prediction, prolonged monitoring, and retrospective diagnosis of pregnancy and infant complications, as well as nutrition management and health products developments of mothers and babies. Here we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other, thus we need to make a diagnosis prudently for those diseases. Based on the microbiome variances and additional anthropometric and physical data, individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable, which is of importance for precise nutrition and probiotics/prebiotics managements and developments. Although a great deal of encouraging performance was manifested in previous studies, the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the future. This review reconceptualizes maternal and infant health from a microbiome perspective, and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.
First Authors:
Shengtao Gao
Correspondence Authors:
Jinfeng Wang
All Authors:
Shengtao Gao,Jinfeng Wang
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