段丽萍团队:肠脑互作障碍中,肠道菌群如何与小胶质细胞的互作?(综述)
创作:Jack Chen 审核:mildbreeze 05月19日
  • 小胶质细胞是中枢神经系统的 “哨兵”,可与肠道菌群互作,共同参与肠脑互动障碍的发生,尤其是肠易激综合征(IBS);
  • 肠道微生物可影响小胶质细胞的发育、成熟和功能,并从免疫、内分泌和神经通路影响IBS中的小胶质细胞;
  • 小胶质细胞可通过潜在的HPA轴、传入和传出神经通路、精神障碍等机制影响肠道菌群;
  • 开发益生菌和益生元等微生态制剂和小檗碱等植物药,研究人脑-肠-菌群互作和小胶质细胞影响肠道菌群的机制,是未来研究方向。
主编推荐语
mildbreeze
肠道微生物群和小胶质细胞在脑-肠互作障碍中有潜在作用。北京大学第三医院段丽萍团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章,重点讨论了肠道菌群和小胶质细胞之间的相互作用在以肠易激综合征为代表的肠脑相互作用障碍中的作用和基本机制,以及相应的临床应用前景,并强调其在治疗精神疾病共病者的肠脑相互作用障碍中的潜力。
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Protein & Cell [IF:21.1]

“Sentinel or accomplice” — gut microbiota and microglia cross-talk in disorders of gut-brain interaction

“哨兵或帮凶”——肠道菌群和小胶质细胞在肠脑互作障碍中的互作

10.1093/procel/pwad020

04-19, Review

Abstract & Authors:展开

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Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction, in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system, which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on disorders of gut-brain interaction, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of disorders of gut-brain interaction, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome. This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of disorders of gut-brain interaction. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in disorders of gut-brain interaction, especially irritable bowel syndrome, and the corresponding clinical application prospects and highlight its potential to treat disorders of gut-brain interaction in individuals with psychiatric comorbidities.

First Authors:
Haonan Zheng,Cunzheng Zhang

Correspondence Authors:
Liping Duan

All Authors:
Haonan Zheng,Cunzheng Zhang,Jindong Zhang,Liping Duan

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