IBD患者确诊前的代谢通路失调
- ①纳入104名IBD患者与208名对照作为发现队列，以及50名IBD患者与25名对照作为验证队列，分析确诊前的血清代谢产物；
- ②初级胆汁酸生物合成、氨基酸代谢、氮代谢、类固醇激素生物合成相关代谢通路的变化与CD相关；
- ③胆汁酸及类固醇激素生物合成的多数代谢产物与CD风险呈负相关，氨基酸代谢及氮代谢的多数代谢产物与CD风险呈正相关；
- ④不饱和脂肪酸生物合成、脂肪酸生物合成相关代谢通路的变化与UC相关，其中多数代谢产物与UC风险呈负相关。
主编推荐语
Gastroenterology上发表的一项最新研究结果，对克罗恩病（CD）与溃疡性结肠炎（UC）患者确诊前的血清代谢产物及代谢通路变化进行了分析，鉴定出了与CD及UC风险相关的代谢通路失调。
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Inflammatory Bowel Disease is Associated with Prediagnostic Perturbances in Metabolic Pathways
IBD与确诊前的代谢通路失调相关
10.1053/j.gastro.2022.09.007
2022-09-16, Article
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Circulating metabolites integrate environmental, genetic, and microbiome data and can serve as illustrative proximal markers of complex diseases. Accordingly, metabolomics profiling has emerged as a novel approach for building mechanistic bridges that link diverse biological pathways to disease phenotype. Alterations in metabolomic profiles have been described in patients with established inflammatory bowel disease (IBD).1 However, metabolomic studies to date have used post-diagnosis samples, where it is impossible to discriminate between signatures associated with IBD etiology and those resulting from IBD. Therefore, we aimed to examine the association between prediagnosis metabolites and metabolic pathways and risk of IBD.
First Authors:
Xinwei Hua,Ryan C Ungaro
Correspondence Authors:
Xinwei Hua,Ryan C Ungaro
All Authors:
Xinwei Hua,Ryan C Ungaro,Lauren M Petrick,Andrew T Chan,Chad K Porter,Hamed Khalili,the Nurses Health Study and PREDICTS Collaborators
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