福建农林大学Science发文：蜜蜂脑部瞬时激活的多巴胺信号调控食物欲望
- ①当蜜蜂离开食物源并开始跳舞传递食物源信息时和刚到饲喂器时，对食物的期望会增加蜜蜂大脑中的多巴胺水平；
- ②多巴胺能信号的药理学阻断，降低了蜜蜂采集频率，增加了在蜂巢中的停留时间，从而增加了连续采集往返时间，表明多巴胺受体拮抗剂（fluphenazine）对采集欲望产生了负面影响；
- ③多巴胺而非5-羟色胺，会影响蜜蜂对蔗糖溶液的反应以及嗅觉相关的食欲和学习。
主编推荐语
哺乳动物中，期望（Wanting）的产生受到中脑边缘多巴胺神经通路调控，但在昆虫中是否存在类似的期望系统尚不清楚。最近，由福建农林大学苏松坤研究员团队牵头，并联合法国图卢兹大学Martin Giurfa教授团队，在Science发表了最新相关研究成果，针对两个科学问题进行了系统研究：采集蜂前往优质食物源的途中是否受欲望系统(Wanting system）驱动？采集蜂在摆尾舞过程中是否通过回忆起优质食物源进而激活欲望系统？结果发现，无论在前往食物源途中还是在摇摆舞中，由于食欲增加和对食物来源的回忆，一个依赖多巴胺的期望系统会在蜜蜂大脑中被暂时激活，表明昆虫与哺乳动物有类似的由积极愉悦刺激产生期望的神经机制。
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Food wanting is mediated by transient activation of dopaminergic signaling in the honey bee brain
食物欲望是由蜜蜂大脑中多巴胺能信号的瞬时激活所介导的
10.1126/science.abn9920
2022-04-28, Article
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The biological bases of wanting have been characterized in mammals, but whether an equivalent wanting system exists in insects remains unknown. In this study, we focused on honey bees, which perform intensive foraging activities to satisfy colony needs, and sought to determine whether foragers leave the hive driven by specific expectations about reward and whether they recollect these expectations during their waggle dances. We monitored foraging and dance behavior and simultaneously quantified and interfered with biogenic amine signaling in the bee brain. We show that a dopamine-dependent wanting system is activated transiently in the bee brain by increased appetite and individual recollection of profitable food sources, both en route to the goal and during waggle dances. Our results show that insects share with mammals common neural mechanisms for encoding wanting of stimuli with positive hedonic value.
First Authors:
Jingnan Huang,Zhaonan Zhang,Wangjiang Feng,Yuanhong Zhao
Correspondence Authors:
Martin Giurfa,Songkun Su
All Authors:
Jingnan Huang,Zhaonan Zhang,Wangjiang Feng,Yuanhong Zhao,Anna Aldanondo,Maria Gabriela de Brito Sanchez,Marco Paoli,Angele Rolland,Zhiguo Li,Hongyi Nie,Yan Lin,Shaowu Zhang,Martin Giurfa,Songkun Su
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