王刚团队：丁基化淀粉可调节肠道菌群，促进PYY分泌缓解PCOS
- ①不同短链脂肪酸（SCFAs）酰化（乙酰化、丙酰化和丁酰化）淀粉可增加大鼠盲肠、结肠和粪便中SCFAs水平。
- ②来曲唑诱导建立大鼠多囊卵巢综合症（PCOS）模型，丁酰化淀粉可缓解大鼠卵巢形态异常、代谢紊乱和性激素失衡症状，而乙酰化和丙酰化淀粉则无明显效果；
- ③丁酰化淀粉通过激活结肠G蛋白偶联受体GRP41并促进PYY分泌缓解PCOS症状；
- ④粪便菌群相比盲肠菌群，受丁酰化淀粉影响更加显著，且粪便中丁酸产生菌可能参与PCOS症状的缓解。
主编推荐语
多囊卵巢综合症 (PCOS) 是一种影响育龄妇女的内分泌疾病。对于大多数 PCOS 患者来说，改变饮食是一种经济有效的方法，几项临床试验已经表明，饮食调节可减少PCOS症状，且不会造成不良影响。PCOS与短链脂肪酸（SCFAs）之间的相关性已被广泛报道，抗性淀粉可通过肠道微生物发酵产生SCFAs，但其对PCOS的缓解仍有待研究。Carbohydrate Polymers近期发表了来自江南大学王刚团队的研究成果，发现SCFAs酰化修饰的抗性淀粉可提高大鼠远端肠内SCFAs水平，证明丁酰化淀粉可通过促进PYY分泌，增加粪便中丁酸产生菌丰度，从而减轻PCOS症状。总之，该研究为酰基化淀粉缓解PCOS症状提供了新的证据，并为使用基于抗性淀粉的饮食疗法干预PCOS提供了有力支持。
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Butylated starch alleviates polycystic ovary syndrome by stimulating the secretion of peptide tyrosine-tyrosine and regulating faecal microbiota
丁基化淀粉通过刺激肽酪氨酸-酪氨酸分泌和调节肠道菌群缓解多囊卵巢综合症
10.1016/j.carbpol.2022.119304
2022-03-02, Article
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Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. Resistant starch can be fermented by gut microbes then produce short-chain fatty acids (SCFAs). It was reported SCFAs might play a key role in gut microbiota-dependent therapy of PCOS. However, the effects of resistant starch on PCOS symptoms have not yet been investigated. Here, maize starch was acylated with specific SCFAs. Our results indicated that acylated starch can release acetate, propionate, and butyrate into the caecum and colon. Treatment with butylated starch (BS) alleviated abnormal ovarian morphology, metabolic disorders, and sex hormone imbalance in letrozole-treated rats, whereas treatment with acetylated starch and propylated starch did not exhibit such effects. Furthermore, BS stimulated the secretion of peptide tyrosine-tyrosine into the serum by activating a G protein-coupled receptor, GPR41, which further affected disease phenotypes. In addition, compared with caecal microbiota, faecal microbiota was more affected by BS. Butyrate-producing microbes were enriched in faeces after BS treatment and may have helped further to relieve PCOS symptoms.
First Authors:
Yufeng He
Correspondence Authors:
Gang Wang
All Authors:
Yufeng He,Liuting Shi,Yajin Qi,Qianqian Wang,Jianxin Zhao,Hao Zhang,Gang Wang,Wei Chen
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