郑钜圣团队：营养-菌群流行病学助力营养、菌群和健康研究，推动精准营养（综述）
- ①食物种类、营养及饮食模式塑造宿主的肠道、口腔、阴道和母乳菌群，菌群反过来影响宿主和后代健康；
- ②菌群代谢物是饮食、菌群和宿主健康间的串扰中的重要中间产物，调节宿主代谢、免疫、神经等功能；
- ③营养-菌群流行病学发现了许多菌群及其代谢组的饮食干预方式和疾病预防靶点，为理解饮食与疾病的关联机制提供了新视角；
- ④肠菌可预测宿主对特定饮食反应的个体间差异，基于肠菌的精准营养为在个体水平上进一步控制和治疗疾病提供了希望。
主编推荐语
饮食和营养对人类微生物组有很大影响，并与微生物组，特别是肠道微生物组相互作用，调节各宿主疾病和健康。微生物组的研究也将营养领域引向了一个更为综合的方向，成为精准营养这一新兴领域的重要组成部分。西湖大学郑钜圣团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章，总结了营养-菌群流行病学领域的最新成果，讨论了饮食、营养、微生物组及其代谢产物之间的相互作用及其对人类健康的影响，随后回顾了基于微生物组的精准营养研究的进展，并介绍了营养-菌群流行病领域目前的局限性、面临的挑战和发展前景。
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Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health
新兴领域：营养-菌群流行病学，研究营养和菌群对人体健康的相互作用
10.1093/procel/pwad023
04-26, Review
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Diet and nutrition have a substantial impact on the human microbiome, and interact with the microbiome, especially gut microbiome, to modulate various diseases and health status. Microbiome research has also guided the nutrition field to a more integrative direction, becoming an essential component of the rising area of precision nutrition. In this review, we provide a broad insight into the interplay among diet, nutrition, microbiome and microbial metabolites for their roles in the human health. Among the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites, we summarize those most reliable findings, and highlight evidence for the relationships between diet and disease-associated microbiome and its functional readout. Then, the latest advances of the microbiome-based precision nutrition research and multi-disciplinary integration are described. Finally, we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.
First Authors:
Wanglong Gou,Zelei Miao,Kui Deng
Correspondence Authors:
Jusheng Zheng
All Authors:
Wanglong Gou,Zelei Miao,Kui Deng,Jusheng Zheng
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