朱书团队：肠道如何感知微生物（综述）
- ①肠道内，toll样受体、nod样受体、RIG-I样受体等模式识别受体可感知微生物分子模式；
- ②G蛋白偶联受体、芳香烃受体和核受体等是感知代谢物的受体；
- ③肠上皮细胞和肠道免疫细胞的调控受微生物感知通路的影响，肠道局部环境信号可作用于固有免疫细胞并调控适应性免疫细胞的分化、迁移和维持，这些细胞抑制宿主对无害抗原的免疫反应并加强肠屏障，维持免疫稳态；
- ④遗传或环境因素引起的微生物感知障碍可导致疾病，如炎症性肠病、1型糖尿病、代谢综合征、神经系统疾病和癌症等。
主编推荐语
宿主和肠道菌群之间互动的第一步，是宿主免疫系统对肠道微生物的感应。中国科技大学朱书团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章，详细总结了感知肠道微生物成分和代谢物的宿主受体和细胞（尤其免疫细胞），并探讨了与肠道微生物感知障碍有关的多种疾病。
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延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Microbial sensing in the intestine
肠道内的微生物感知
10.1093/procel/pwad028
05-16, Review
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The gut microbiota plays a key role in host health and disease, particularly through their interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic relationships between the host and the diverse gut microbiota, which is influenced by the highly co-evolved immune-microbiota interactions. The first step of the interaction between the host and the gut microbiota is the sensing of the gut microbes by the host immune system. In this review, we describe the cells of the host immune system and the proteins that sense the components and metabolites of the gut microbes. We further highlight the essential roles of pattern recognition receptors (PRRs), the G protein coupled receptors (GPCRs), aryl hydrocarbon receptor (AHR) and the nuclear receptors expressed in the intestinal epithelial cells (IECs) and the intestine-resident immune cells. We also discuss the mechanisms by which the disruption of microbial sensing because of genetic or environmental factors causes human diseases such as the inflammatory bowel disease (IBD).
First Authors:
Tingting Wan,Yalong Wang,Kaixin He
Correspondence Authors:
Shu Zhu
All Authors:
Tingting Wan,Yalong Wang,Kaixin He,Shu Zhu
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