口腔炎症与IBD的密切关系（观点）
- ①流行病学研究表明，炎症性肠病（IBD）可能与牙周炎有关；
- ②这两种复杂疾病都涉及异常免疫反应和菌群失调，二者的互作可在易感个体中引发慢性炎症和组织损伤；
- ③口腔影响肠道炎症的途径包括：口腔炎症细菌移位至肠道，以及口腔内活化的T细胞通过血液和淋巴迁移至肠道，进而促进肠道炎症；
- ④初步研究表明，牙周炎治疗可减少全身免疫激活，治疗IBD也与牙周炎愈合相关，但目前仍缺乏临床试验数据来确定其临床意义。
主编推荐语
Trends in Molecular Medicine近期发表观点文章，讨论了牙周炎与炎症性肠病（IBD）间的潜在关联和机制，以及对临床实践的意义。
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延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Pathogenic associations between oral and gastrointestinal diseases
口腔和胃肠道疾病之间的致病联系
10.1016/j.molmed.2022.05.006
2022-06-09, Article
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Both periodontitis and inflammatory bowel disease (IBD) are complex chronic conditions characterized by aberrant host immune response and dysregulated microbiota. Emerging data show an association between periodontitis and IBD, including direct and indirect mechanistic links between oral and intestinal inflammation. Direct pathways include translocation of proinflammatory microbes from the oral cavity to the gut and immune priming. Indirect pathways involve systemic immune activation with possible nonspecific effects on the gut. There are limited data on the effects of periodontal disease treatment on IBD course and vice versa, but early reports suggest that treatment of periodontitis decreases systemic immune activation and that treatment of IBD is associated with periodontitis healing, underscoring the importance of recognizing and treating both conditions.
First Authors:
Kira L Newman
Correspondence Authors:
Nobuhiko Kamada
All Authors:
Kira L Newman,Nobuhiko Kamada
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