Science：霍乱弧菌拮抗肠道菌群以提高毒力与适应性
- ①霍乱弧菌的VI型分泌系统（T6SS）是一种纳米机器，将毒性效应蛋白递送到靶细胞中并杀伤细胞；
- ②在小鼠体内发现，T6SS可攻击宿主共生菌群的成员，促进了病原体对肠道的定殖；
- ③这种菌群间的拮抗互作通过增强细菌的肠道定殖、毒力基因表达，并激活宿主的先天性免疫基因，以驱动霍乱弧菌的致病性显著增加；
- ④霍乱弧菌对肠道菌群的拮抗作用通过提升其传播至新的易感宿主中的能力，增加了其在小鼠体内的适应性。
主编推荐语
这是Science[IF：37.205]在上期发表的一项重要的特定病原菌（霍乱弧菌）是如何攻击肠道菌群中的其他细菌，从而实现毒力和适应性都增强的目的的研究，揭开了病原菌定殖肠道的全新机制，很值得专业人士特别关注。
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Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence
对肠道菌群的拮抗作用及其对霍乱弧菌毒力的影响
10.1126/science.aap8775
2018-01-12, Article
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The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced intestinal colonization, expression of bacterial virulence genes, and activation of host innate immune genes. Because ablation of mouse commensals by this enteric pathogen correlated with more severe diarrheal symptoms, we conclude that antagonism toward the gut microbiota could improve the fitness of V. cholerae as a pathogen by elevating its transmission to new susceptible hosts.
First Authors:
Wenjing Zhao
Correspondence Authors:
John J Mekalanos
All Authors:
Wenjing Zhao,Florence Caro,William Robins,John J Mekalanos
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