国内团队：基于垂直和水平方向群体感应的多细胞交流（综述）
- ①关于QS（群体感应）的研究已经从分子水平发展到菌株水平和群落水平；
- ②基于QS的互作可以分为垂直互作（基于群体感应的细菌-噬菌体互作和细菌-宿主互作）和水平互作（基于QS的两株细菌和多株细菌间的互作）；
- ③微生物可以产生和/或响应与宿主相同的信号分子；
- ④基于水平QS的互作可用于构建多组分合成菌群；
- ⑤操纵各种QS信号的水平，如AI-2，吲哚，DSFs和CAI-1，可影响QS通信网络，进而减少抗生素耐药性和缓解肠道菌群失调等。
主编推荐语
群体感应（Quorum sensing，QS）在微生物系统中起着重要的作用。Trends in Microbiology发表的来自天津大学乔建军和刘春江团队的综述文章，将基于QS的互作分为垂直互作和水平互作。对于垂直互作，综述主要讨论了自然微生物系统中噬菌体、细菌和宿主之间基于QS信号和激素的相互作用。而对于水平互作，文章强调了多组分合成微生物菌群基于QS互作的操作。同时，文章还介绍了操纵“QS通信网络”在天然和合成微生物系统中的最新应用，并进一步提出了未来设计不同QS通信网络的关键挑战。推荐阅读！
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Vertical and horizontal quorum-sensing-based multicellular communications
基于垂直和水平群体感应的多细胞交流
10.1016/j.tim.2021.04.006
2021-05-18, Review
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Quorum sensing (QS) plays an important role in both natural and synthetic microbial systems. The complexity of QS entails multilayer controls, biomolecular crosstalk, and population-based interactions. In this review, we divide complex QS-based interactions into vertical and horizontal interactions. With respect to the former, we discuss QS-based interactions among phages, bacteria, and hosts in natural microbial systems, which are based on various QS signals and hormones. With regard to the latter, we highlight manipulations of QS-based interactions for multicomponent synthetic microbial consortia. We further present the recent and emerging applications of manipulating these interactions (collectively referred to as 'QS communication networks') in natural and synthetic microbiota. Finally, we identify key challenges in engineering diverse QS communication networks for various future applications.
First Authors:
Shengbo Wu,Chengyang Xu
Correspondence Authors:
Chunjiang Liu,Jianjun Qiao
All Authors:
Shengbo Wu,Chengyang Xu,Jiaheng Liu,Chunjiang Liu,Jianjun Qiao
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