婴儿喂养方式影响口腔菌群
- ①纳入448对母婴，在4个月时采集舌拭子样本进行微生物检测；
- ②尽管婴儿和母亲的口腔菌群结构有着明显的不同，但在母婴对中，共享的扩增子序列平均占9.7%，高于无血缘关系的女性和婴儿对；
- ③这种相同的扩增子比例与婴儿的喂养方式密切相关，配方奶喂养的婴儿的比例较纯母乳喂养的婴儿高；
- ④但与婴儿的分娩方式或抗生素暴露无关；
- ⑤这些数据增加对婴儿口腔菌群的早期发展及其与口腔菌群相关疾病的潜在联系的了解。
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本研究通过婴儿及其母亲口腔菌群的检测，发现两者之间存在关联，并且这种关联受喂养方式的影响。鉴于儿童期口腔菌群的重要作用，本研究为探寻儿童健康的干预靶点提供了依据。
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High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota
配方奶喂养的婴儿口腔微生物群中获取高水平的母体口腔细菌
10.1128/mbio.03452-21
2022-01-18, Article
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The influx of maternal oral microbes is considered to play an important role in the acquisition and development of infant oral microbiota. In this study, we examined tongue swab samples from 448 mother-infant pairs at 4-month checkups. The bacterial composition of each sample was determined using PacBio single-molecule long-read sequencing of the full-length 16S rRNA gene and the amplicon sequence variant (ASV) approach. Although the infant oral microbiota was distinctly different from the mother oral microbiota, ASVs shared with their biological mother accounted for a median relative abundance of 9.7% (range of 0.0 to 99.3%), which was significantly higher than that of ASVs shared with unrelated mothers. This shared abundance was strongly associated with the feeding method of infants rather than their delivery mode or antibiotic exposure, and formula-fed infants had higher shared abundance than exclusively breastfed infants. Our study presents strain-level evidence for mother-to-infant transmission of oral bacteria and suggests that colonization of maternal oral bacteria is higher in formula-fed infants. Acquisition of oral bacteria during infancy can affect the subsequent formation of stable oral microbiota. This study focused on the mother-to-infant transmission of oral bacteria, a major acquisition route of infant oral microbiota, and demonstrated that most infants acquired oral bacteria from their biological mother even at the single-nucleotide level. Our results also indicated that the occupancies of maternal oral bacteria in infant oral microbiota were associated with the feeding methods of infants. These data could increase understanding of the early development of oral microbiota in infants and its potential associations with oral microbiota-related diseases.
First Authors:
Shinya Kageyama
Correspondence Authors:
Yoshihisa Yamashita
All Authors:
Shinya Kageyama,Michiko Furuta,Toru Takeshita,Jiale Ma,Mikari Asakawa,Yoshihisa Yamashita
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