国内团队Nature子刊：环境友好的可降解塑料可导致小鼠肠道炎症
- ①在胃肠道中的可降解甘油三酯的脂肪酶的催化下，聚乳酸塑料微粒可被水解，并在疏水作用驱动下自聚集形成低聚物纳米颗粒；
- ②在小鼠模型中，聚乳酸低聚物及其纳米颗粒可在肝脏、肠道及脑中聚集，低剂量的聚乳酸塑料微粒暴露可导致肠道损伤及急性炎症；
- ③机制上，聚乳酸低聚物可与基质金属蛋白酶12的催化锌指结构域高亲和力结合，导致后者失活，从而介导肠道炎症。
主编推荐语
"生态友好"的可生物降解塑料被认为可用于减少塑料污染，但其健康风险及对胃肠道的影响尚不清楚。复旦大学的方明亮团队、陈建民团队与安徽医科大学的黄以超团队在Nature Nanotechnology上发表的一项最新研究结果，聚乳酸塑料微粒可在胃肠道中被脂肪酶降解，形成的低聚物纳米颗粒可导致基质金属蛋白酶12失活，从而导致小鼠的肠道炎症。
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Oligomer nanoparticle release from polylactic acid plastics catalysed by gut enzymes triggers acute inflammation
肠道酶催化的聚乳酸塑料释放的低聚物纳米颗粒驱动急性炎症
10.1038/s41565-023-01329-y
03-02, Article
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The health risks of exposure to ‘eco-friendly’ biodegradable plastics of anthropogenic origin and their effects on the gastrointestinal tract are largely unknown. Here we demonstrate that the enzymatic hydrolysis of polylactic acid microplastics generated nanoplastic particles by competing for triglyceride-degrading lipase during gastrointestinal processes. Nanoparticle oligomers were formed by hydrophobically driven self-aggregation. In a mouse model, polylactic acid oligomers and their nanoparticles bioaccumulated in the liver, intestine and brain. Hydrolysed oligomers caused intestinal damage and acute inflammation. A large-scale pharmacophore model revealed that oligomers interacted with matrix metallopeptidase 12. Mechanistically, high binding affinity (Kd = 13.3 μmol l−1) of oligomers to the catalytic zinc-ion finger domain led to matrix metallopeptidase 12 inactivation, which might mediate the adverse bowel inflammatory effects after exposure to polylactic acid oligomers. Biodegradable plastics are considered to be a solution to address environmental plastic pollution. Thus, understanding the gastrointestinal fates and toxicities of bioplastics will provide insights into potential health risks.
First Authors:
Mengjing Wang
Correspondence Authors:
Yichao Huang,Jianmin Chen,Mingliang Fang
All Authors:
Mengjing Wang,Qianqian Li,Changzhi Shi,Jia Lv,Youdong Xu,Junjie Yang,Shae Linn Chua,Linran Jia,Huaiwen Chen,Qian Liu,Changjin Huang,Yichao Huang,Jianmin Chen,Mingliang Fang
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