刘宏伟团队：肠菌细胞壁的免疫原性分子（综述）
- ①源自肠道细菌细胞壁的免疫原性分子肽聚糖和脂质相关分子等，具有不同的结构特征，在健康和疾病中塑造固有免疫和适应性免疫应答；
- ②肽聚糖及其衍生物通过与细胞内固有免疫受体NOD1/2结合，调节宿主免疫和炎症反应；
- ③肠菌细胞壁衍生的脂质相关分子（糖脂类、磷酯类等）可通过调节细胞外固有免疫受体（如TRLs）介导的通路或特异性T细胞群，调节固有免疫和适应性免疫应答；
- ④仅一小部分肠道共生菌衍生的免疫活性物质被探索过。
主编推荐语
在宿主-肠道菌群之间，来自肠道共生细菌的细胞壁衍生分子在训练和重塑宿主免疫反应中发挥着关键作用。中科院微生物所刘宏伟团队在在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章，聚焦肽聚糖和脂质相关分子等肠菌细胞壁衍生的免疫源性分子，总结了其结构特征、免疫反应和基本机制。肠菌细胞壁衍生的成分或可作为治疗感染和免疫疾病的重要药物来源。
关键字
延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms
肠道细菌细胞壁相关的免疫原性分子：化学结构、免疫调节功能和机制
10.1093/procel/pwad016
04-04, Review
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Interactions between gut microbiome and host immune system are fundamental to maintaining the intestinal mucosal barrier and homeostasis. At the host-gut microbiome interface, cell wall-derived molecules from gut commensal bacteria have been reported to play a pivotal role in training and remodeling host immune responses. In this article, we review gut bacterial cell wall-derived molecules with characterized chemical structures, including peptidoglycan and lipid-related molecules that impact host health and disease processes via regulating innate and adaptive immunity. Also, we aim to discuss the structures, immune responses and underlying mechanisms of these immunogenic molecules. Based on current advances, we propose cell wall-derived components as important sources of medicinal agents for the treatment of infection and immune diseases.
First Authors:
Ruopeng Yin,Tao Wang
Correspondence Authors:
Hongwei Liu
All Authors:
Ruopeng Yin,Tao Wang,Huanqin Dai,Junjie Han,Jingzu Sun,Ningning Liu,Wang Dong,Jin Zhong,Hongwei Liu
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