周永健团队：粪菌移植+低FODMAP饮食，可长期缓解IBS
- ①纳入80例难治性腹泻型肠易激综合征患者，对比粪菌移植（FMT组，40人）和FMT联合低FODMAP饮食（FMT+LFD组，40人）的治疗效果；
- ②FMT+LFD组第1、3、6个月时缓解率均高于FMT组（70.0% vs. 55.0%、67.5% vs. 57.5%、62.5% vs. 27.5%）；
- ③FMT+LFD组第1、3、6个月的生活质量、第6个月的严重程度评分、第1个月的胃肠道症状评分改善优于FMT组；
- ④LFD增加了FMT诱导的肠道菌群多样性，且拟杆菌属、另枝菌属等相对增加，双歧杆菌属等相对减少。
主编推荐语
粪菌移植（FMT）和饮食干预越来越多的用于肠易激综合征（IBS）的临床治疗。已有的研究表明，低FODMAP饮食（LFD）可有效改善IBS症状（FODMAP：可发酵低聚糖、双糖、单糖和多元醇）。近日，广州市第一人民医院（华南理工大学附属第二医院）周永健、Hao-Ming Xu及其团队在Oxidative Medicine and Cellular Longevity上发表文章，回顾性对比了FMT、FMT+LFD联用对腹泻型IBS治疗的效果，发现低FODMAP饮食可增强FMT的疗效、改善肠道菌群，实现IBS症状的长期缓解。
关键字
延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Fecal Microbiota Transplantation Combined with a Low FODMAP Diet for the Treatment of Irritable Bowel Syndrome with Predominant Diarrhea
粪菌移植联合低FODMAP饮食治疗腹泻型肠易激综合征
10.1155/2022/5121496
2022-09-21, Article
Abstract & Authors:展开
Abstract:收起
Background. Fecal microbiota transplantation (FMT) has been found to be effective in irritable bowel syndrome with predominant diarrhea (IBS-D). We conducted this study to determine the impact of a low FODMAP diet (LFD) on the gut microbiota and the efficacy of FMT in the treatment of IBS-D. Methods. A retrospective analysis of a single-arm open-label prospective study was conducted to investigate the impact of FMT alone () and FMT+LFD () in refractory IBS-D. The IBS-quality of life (QOL), IBS-severity scoring system (SSS), gastrointestinal symptom rating scale (GSRS), Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD) were used to evaluate the efficacy, and partial 16S rDNA amplicon sequencing was used to profile the microbiota. Results. The response rates were higher in the FMT+LFD group than in the FMT group (1 mo, 3 mo, 6 mo: 70.0% vs. 55.0%, 67.5% vs. 57.5%, 62.5% vs. 27.5%, respectively). The FMT+LFD group showed significantly better improvement in IBS-QOL at 1, 3, and 6 months; IBS-SSS at 6 months; and GSRS at 1 month compared to FMT alone. Changes in HAMA and HAMD were similar in the two groups. The LFD significantly upregulated the FMT-induced microbial diversity (OTUs: 666 vs. 574, Adonis: ) and significantly strengthened the upregulation of Bacteroides, Alistipes, and Ruminococcaceae_UCG-002 and the downregulation of Bifidobacterium. Conclusion. An LFD enhanced the efficacy of FMT, increased the gut microbial diversity after FMT, and strengthened the inhibitory effect of FMT on conditional pathogens.
First Authors:
Hongli Huang
Correspondence Authors:
Hao-Ming Xu,Yongjian Zhou
All Authors:
Hongli Huang,Jia-Qi Zhu,Liu-Si Yang,Qiong Wu,Di-Wen Shou,Hui-Ting Chen,Jun Ma,Yong-Qiang Li,Hao-Ming Xu,Yongjian Zhou
评论
