程功团队:菌群如何影响蚊媒疾病(综述)
创作:阿当 审核:mildbreeze 05月19日
  • 蚊子肠道菌群可直接(分泌化学物质/酶、诱导免疫反应和改变中肠的屏障/生化环境)和间接(改变蚊子生物学、种群密度、生存和叮咬)影响蚊媒疾病传播,沃尔巴克氏菌为代表的蚊子共生菌可控制蚊媒疾病;
  • 动物皮肤菌群产生吸引或驱蚊的挥发物,影响蚊子寻找宿主,从而影响蚊媒疾病传播;
  • 人肠道菌群通过促进健康皮肤、调节皮肤免疫,诱导全身性抗病毒I型IFN应答,影响蚊媒疾病的进展;
  • 进一步研究蚊子、宿主、病原体及其菌群间的相互作用,或是防控蚊媒疾病的关键。
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mildbreeze
蚊媒疾病对人类健康构成重大威胁,然而目前防治这些疾病的措施仍不尽如人意。清华大学程功团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述,总结了关于蚊子和脊椎动物微生物组对蚊媒疾病影响的最新研究进展,表明微生物组或可为防控这类疾病提供新的思路和举措。
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Protein & Cell [IF:21.1]

Impact of the microbiome on mosquito-borne diseases

菌群对蚊媒疾病的影响

10.1093/procel/pwad021

04-25, Article

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Mosquito-borne diseases present a significant threat to human health, with the possibility of outbreaks of new mosquito-borne diseases always looming. Unfortunately, current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective. However, recent studies on microbiomes may reveal promising strategies to fight these diseases. In this review, we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases. We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases, with mosquito symbiotic microorganisms, particularly Wolbachia bacteria, showing potential for controlling mosquito-borne diseases. Moreover, the skin microbiome of vertebrates plays a significant role in mosquito preferences, while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans. As researchers continue to explore the role of microbiomes in mosquito-borne diseases, we highlight some promising future directions for this field. Ultimately, a better understanding of the interplay between mosquitoes, their hosts, pathogens, and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.

First Authors:
Huicheng Shi

Correspondence Authors:
Gong Cheng

All Authors:
Huicheng Shi,Xi Yu,Gong Cheng

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