Cell：睡眠太少促早死，是因为伤在肠道？
- ①严重睡眠剥夺能导致果蝇早死；
- ②使用3种不同的睡眠剥夺方法发现，缺乏睡眠能导致活性氧（ROS）在果蝇肠道（而非其它组织器官）大量积累，引起氧化应激反应（如DNA损伤和细胞死亡），这些异常在停止睡眠剥夺后能逐渐恢复；
- ③小鼠中，睡眠剥夺也导致ROS在肠道积累（尤其是小肠），引起氧化应激和细胞损伤；
- ④肠内ROS积累是驱动早死的原因，口服补充抗氧化剂或在肠道表达抗氧化酶以防止ROS在肠内积累，能使缺乏睡眠的果蝇恢复正常寿命。
主编推荐语
缺乏睡眠损害健康，在多种模式生物中，严重的睡眠剥夺可导致动物早死，但是人们并不清楚这个现象背后的原因和机制。《Cell》最新发表了一项来自哈佛医学院的研究，发现睡眠不足可导致肠道内积累大量活性氧自由基，引起肠道的氧化应激损伤，并在果蝇中证明这种肠内的活性氧积累正是严重睡眠不足促进早死的原因。对于改善睡眠不足带来的健康问题，这项研究或许能提供一些新思路。
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Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
睡眠不足通过肠道内活性氧的积累导致死亡
10.1016/j.cell.2020.04.049
2020-06-04, Article
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The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown. Here we show, using flies and mice, that sleep deprivation leads to accumulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut. ROS are not just correlates of sleep deprivation but drivers of death: their neutralization prevents oxidative stress and allows flies to have a normal lifespan with little to no sleep. The rescue can be achieved with oral antioxidant compounds or with gut-targeted transgenic expression of antioxidant enzymes. We conclude that death upon severe sleep restriction can be caused by oxidative stress, that the gut is central in this process, and that survival without sleep is possible when ROS accumulation is prevented.
First Authors:
Alexandra Vaccaro,Yosef Kaplan Dor
Correspondence Authors:
Dragana Rogulja
All Authors:
Alexandra Vaccaro,Yosef Kaplan Dor,Keishi Nambara,Elizabeth A Pollina,Cindy Lin,Michael E Greenberg,Dragana Rogulja
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