刘星吟团队：神经发育疾病中的菌群-肠-脑轴（综述）
- ①孤独症谱系障碍、注意力缺陷多动障碍、雷特综合征等神经发育疾病与菌群-肠-脑轴有关，菌群干预在治疗神经发育疾病上具有潜力；
- ②肠菌自身、代谢物和细胞壁成分可与免疫细胞互作，诱导免疫细胞及其分泌因子，肠道局部免疫经系统循环影响大脑神经发育，小胶质细胞是重要介质；
- ③肠道菌群通过HN轴和HPA轴等内分泌/系统途径调控神经发育，肠菌产生神经活性分子（如5AV、牛磺酸、4EPS）可影响大脑；
- ④受肠菌调控的肠道5-HT以及菌群代谢物等分子可通过肠神经系统和迷走神经等神经途径影响大脑。
主编推荐语
菌群-肠-脑轴在神经发育疾病中的作用得到了越来越多的研究重视。南京医科大学刘星吟团队在Protein & Cell 2023肠道大会微生物组专刊中发表综述文章，详细介绍了肠道菌群通过免疫途径、神经途径和内分泌/系统途径调节神经发育的机制，及其与多种神经发育疾病的关系和临床应用潜力。
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The microbiota-gut-brain axis and neurodevelopmental disorders
微生物群-肠-脑轴与神经发育障碍
10.1093/procel/pwad026
05-11, Review
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The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. In recent years, the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly appreciated. The gut microbiota is commonly considered to regulate neurodevelopment through three pathways, the immune pathway, the neuronal pathway, and the endocrine/systemic pathway, with overlaps and crosstalks in between. Accumulating studies have identified the role of the microbiota-gut-brain axis in neurodevelopmental disorders including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and Rett Syndrome. The major aims of this review are to, first of all, discuss the mechanisms of the microbial regulation of neurodevelopment alongside the aforementioned three pathways on both the molecular and systemic scales; and second of all, present evidence for the roles of the microbiota-gut-brain axis in various neurodevelopmental disorders, the underlying mechanisms, and the potential therapeutic methods. Finally, we discuss the current situation in the field and propose the paucity in the exploration of the specific mechanisms of the microbiota-gut-brain axis in neurodevelopmental disorders.
First Authors:
Qinwen Wang,Qianyue Yang
Correspondence Authors:
Xingyin Liu
All Authors:
Qinwen Wang,Qianyue Yang,Xingyin Liu
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