同济大学：一文读懂饮食如何调节健康和疾病（综述）
- ①现有的饮食调节手段包括：禁食、热量限制、宏量营养素干预、氨基酸干预（如甲硫氨酸限制）、微量营养素干预、代谢产物干预（如补充亚精胺）；
- ②饮食主要通过两种机制调节健康与疾病：营养介导的机制（代谢调节因子、营养代谢途径、表观遗传机制、生物钟）、饮食应答效应器（饮食-内分泌、免疫、肠道、衰老及神经轴）；
- ③饮食干预已用于代谢综合征、心血管疾病、肠道功能障碍、肾病、内分泌疾病、呼吸系统疾病及癌症的临床试验中。
主编推荐语
同济大学的王平团队在Signal Transduction and Targeted Therapy上发表的一篇综述文章，概述了在临床前模型及临床试验中使用的各类饮食干预手段，并详细介绍了饮食干预调节健康与疾病的两种主要机制：营养介导的机制及饮食应答效应器。
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延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
Dietary regulation in health and disease
健康和疾病中的饮食调节
10.1038/s41392-022-01104-w
2022-07-23, Article
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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.
First Authors:
Qi Wu,Zhi-Jie Gao
Correspondence Authors:
Ping Wang
All Authors:
Qi Wu,Zhi-Jie Gao,Xin Yu,Ping Wang
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