难消化淀粉颗粒富集特定微生物，诱导产生乙酸和丁酸
- ①青春双歧杆菌能在抗性淀粉颗粒表面密集、频繁定殖；
- ②青春双歧杆菌携带者在摄入生马铃薯淀粉(pSt)后，青春期双歧杆菌丰度增加，乙酸和乳酸浓度增加，丙酸盐浓度降低；
- ③非携带者中，另一种利用淀粉的直肠真杆菌及其代谢物丁酸盐增加，但这在携带者中受到抑制；
- ④在淀粉颗粒降解菌布氏瘤胃球菌竞争下，青春双歧杆菌也可以在 pSt 表面定殖；
- ⑤青春双歧杆菌或直肠真杆菌特异性结合pSt，选择性地诱导肠道菌群产乙酸或产丁酸，前者占主导。
主编推荐语
预测个体化反应是饮食干预调节人类肠道微生物群的最大挑战之一。细菌对饮食因素的种间竞争是微生物反应的主体间异质性的基础。肠道食物结构周围细菌物种的微观定位可以为此提供直接证据。ISME Journal发表的文章表明，青春双歧杆菌或直肠真杆菌与pSt的特异性结合可以选择性地诱导肠道微生物群的乙酰化或丁酰化反应。本研究结果或为理解类似的种间关系提供理论方法基础，并有利于提出精确控制微生物群的方法策略。
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Selective induction of human gut-associated acetogenic/butyrogenic microbiota based on specific microbial colonization of indigestible starch granules
基于难消化淀粉颗粒的特定微生物选择性诱导人类肠道相关的产乙酸/产酸微生物群
10.1038/s41396-022-01196-w
2022-02-03, Article
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Prediction of individualized responses is one of biggest challenges in dietary intervention to modulate human gut microbiota. Bacterial interspecies competition for dietary factors should underlie the inter-subject heterogeneity of microbial responses. Microscale localization of bacterial species around intestinal food structures could provide direct evidence for understanding this, however, little information is currently available. Here we analyzed human fecal sections and found multiple types of bacterial colonization of food structures. The most eminent one was dense and frequent colonization of starch granules by Bifidobacterium adolescentis. After intake of raw potato starch (pSt), B. adolescentis dramatically increased in every carrier of the species, accompanied by an increase in bifidobacterial metabolite acetate. In the other subjects, Eubacterium rectale and its metabolite butyrate increased, but it was suppressed in B. adolescentis carriers. A correlation analysis indicated the contribution of these species to respective metabolites. In vitro analyses of isolates of major gut bacterial species confirmed that these species are major colonizers of pSt and that B. adolescentis can colonize pSt even in the presence of the known starch granule-degrading bacterium Ruminococcus bromii. Collectively, we propose that specific binding of B. adolescentis or E. rectale to pSt selectively induces acetogenic or butyrogenic response of gut microbiota, where the former determines the response of the latter.
First Authors:
Yusuke Nagara
Correspondence Authors:
Yusuke Nagara
All Authors:
Yusuke Nagara,Daichi Fujii,Toshihiko Takada,Mikiko Sato-Yamazaki,Toru Odani,Kenji Oishi
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