菊粉可改善乳糜泻患儿的氨基酸代谢
- ①遵循无麸质饮食（CFD）的乳糜泻患儿随机分组，一组给予富含低聚果糖的菊粉3个月，一组给予安慰剂，检测干预前后血液和尿液中氨基酸（AA）谱；
- ②两组的血浆中多种AA均显著增加，谷氨酰胺仅在菊粉干预组增加；
- ③干预组尿液中天冬酰胺、赖氨酸和α氨基己二酸增加，而安慰剂组天冬氨酸和甲硫氨酸减少，两组尿中谷氨酰胺与谷氨酸之比增加；
- ④归因于AA吸收和代谢增强及肠粘膜的愈合；
- ⑤菊粉改善肠道状况和渗透性，益生元+GFD对患儿AA代谢有益。
主编推荐语
乳糜泻患者中常见氨基酸失衡。Amino Acids发表一项随机对照的初步研究，在34名乳糜泻患儿中证实在无麸质饮食的基础上，补充富含低聚果糖的菊粉可改善患儿的氨基酸代谢情况。
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Plasma profile and urine excretion of amino acids in children with celiac disease on gluten-free diet after oligofructose-enriched inulin intervention: results of a randomised placebo-controlled pilot study
采用无麸质饮食的乳糜泻患儿经富含低聚果糖的菊粉干预后血浆和尿液氨基酸谱： 随机安慰剂对照初步研究的结果
10.1007/s00726-018-2622-7
2018-07-24, Article
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The circulating amino acid (AAs) concentrations are indicators of dietary protein intake and metabolic status. In celiac disease (CD), the AA imbalance is frequently observed. Prebiotics are found to alleviate nutrient deficiencies. Therefore, the aim of this study was to analyse the impact of oligrofructose-enriched inulin (Synergy 1), administered for 3 months as a gluten-free diet (GFD) supplement to children with CD, on the plasma and urine concentrations of AAs. CD children (N = 34) were randomised into two groups, receiving Synergy 1 (10 g/day) or placebo (maltodextrin) for 3 months. The AA profile and concentration was determined in plasma and urine before and after the dietary intervention by gas chromatography. 22 and 28 AAs were determined in plasma and urine samples, respectively. After the intervention, the plasma concentrations of several AAs (Ala, Pro, Asn, Glu, Tyr, Lys, His, Orn) increased significantly in both experimental groups, while Gln increased only in the Synergy 1 group. The urinary excretion of Asn, Lys and Aaa increased significantly in the Synergy 1 group, and the excretion of Asp and Met decreased (p < 0.05) in the placebo group. The Gln:Glu ratio in urine increased in both groups after the intervention. An increased urinary excretion of AAs observed in Synergy 1 group with a simultaneous increase in the content of circulating AAs could be attributed to higher absorption or intensified metabolism of AAs, and on the other hand further healing of the intestinal mucosa being the result of continuous treatment with GFD. Moreover, the observed changes in Glu concentration suggest that oligofructose-enriched inulin could improve the intestinal condition and permeability. To conclude, a prebiotic-supplemented GFD influences beneficially the overall AAs metabolism in CD children; however, further prospective cohort studies are needed to confirm the results obtained.
First Authors:
Natalia Drabińska
Correspondence Authors:
Natalia Drabińska,Urszula Krupa-Kozak
All Authors:
Natalia Drabińska,Urszula Krupa-Kozak,Ewa Ciska,Elżbieta Jarocka-Cyrta
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