谢鹏+魏泓等：精神分裂症的潜在菌群-肠-脑轴机制
- ①与健康对照（HC）相比，精神分裂症（SCZ）患者肠道菌群的α-多样性降低，且菌群组成改变：韦荣球菌科等的23个OTU增多，毛螺菌科等的54个OTU减少；
- ②鉴定出与SCZ严重程度相关的7个OTU，用气球菌科、双歧杆菌科、布鲁氏菌科、巴斯德氏菌科和理研菌科作为标志物，可较准确的区分SCZ与HC（AUC=0.769）；
- ③与HC相比，移植SCZ菌群的小鼠表现出SCZ相关行为，海马区中谷氨酸水平较低、谷氨酰胺和GABA水平较高，肠脑轴氨基酸和脂代谢通路改变。
主编推荐语
精神分裂症（SCZ）是一类病因未明的精神疾病，与遗传和环境因素有关。Science Advances发表来自谢鹏团队和魏泓团队等合作的最新研究，鉴定出与SCZ相关的肠道菌群特征，或能用于疾病诊断；并用粪菌移植和代谢组学等方法在小鼠中表明，SCZ菌群可能通过菌群-肠-脑轴机制影响神经化学和神经功能，参与SCZ发病。这些发现提示，靶向肠道菌群的疗法或能用于改善SCZ。
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The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
来自精神分裂症患者的肠道微生物组可调节小鼠的谷氨酸-谷氨酰胺-GABA循环和精神分裂症相关行为
10.1126/sciadv.aau8317
2019-02-06, Article
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Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to HCs, germ-free mice receiving SCZ microbiome fecal transplants had lower glutamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction. Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology.
First Authors:
Peng Zheng,Benhua Zeng
Correspondence Authors:
Julio Licinio,Hong Wei,Peng Xie
All Authors:
Peng Zheng,Benhua Zeng,Meiling Liu,Jianjun Chen,Junxi Pan,Yu Han,Yiyun Liu,Ke Cheng,Chanjuan Zhou,Haiyang Wang,Xinyu Zhou,Siwen Gui,Seth W Perry,Ma-Li Wong,Julio Licinio,Hong Wei,Peng Xie
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