肠道菌群调节败血症患者与健康人的体温
- ①鉴定出败血症患者的4种体温变化模式（高温+缓慢缓解、高温+快速缓解、正常体温、低温），低温患者的死亡率最高；
- ②败血症患者住院时的肠道菌群可预测其体温变化模式；
- ③在正常小鼠中，败血症期间的体温变化差异可被肠道菌群差异所解释；
- ④无菌小鼠及抗生素处理小鼠的基础体温均低于正常小鼠，且相比于正常小鼠，无菌小鼠在败血症期间的体温降低；
- ⑤毛螺菌科与败血症患者、败血症小鼠及抗生素处理小鼠的体温变化模式均相关。
主编推荐语
American Journal of Respiratory and Critical Care Medicine上发表的一项最新研究结果，在败血症患者中发现，肠道菌群与体温变化密切相关，而体温变化与临床结局相关。在小鼠中，也可观察到肠道菌群与体温相关，且肠道菌群的差异与败血症期间的体温变化相关。
关键字
延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
The Gut Microbiome Modulates Body Temperature Both in Sepsis and Health
10.1164/rccm.202201-0161OC
2022-11-15, Article
Abstract & Authors:展开
Abstract:收起
Rationale: Among patients with sepsis, variation in temperature trajectories predicts clinical outcomes. In healthy individuals, normal body temperature is variable and has decreased consistently since the 1860s. The biologic underpinnings of this temperature variation in disease and health are unknown. Objectives: To establish and interrogate the role of the gut microbiome in calibrating body temperature. Methods: We performed a series of translational analyses and experiments to determine whether and how variation in gut microbiota explains variation in body temperature in sepsis and in health. We studied patient temperature trajectories using electronic medical record data. We characterized gut microbiota in hospitalized patients using 16S ribosomal RNA gene sequencing. We modeled sepsis using intraperitoneal lipopolysaccharide in mice and modulated the microbiome using antibiotics, germ-free, and gnotobiotic animals. Measurements and main results: Consistent with prior work, we identified four temperature trajectories in patients hospitalized with sepsis that predicted clinical outcomes. In a separate cohort of 116 hospitalized patients, we found that composition of patients’ gut microbiota at admission predicted their temperature trajectories. Compared with conventional mice, germ-free mice had reduced temperature loss during experimental sepsis. Among conventional mice, heterogeneity of temperature response in sepsis was strongly explained by variation in gut microbiota. Healthy germ-free and antibiotic-treated mice both had lower basal body temperatures when compared to controls. The Lachnospiraceae family was consistently associated with temperature trajectories in hospitalized patients, experimental sepsis, and antibiotic-treated mice. Conclusions: The gut microbiome is a key modulator of body temperature variation both in health and critical illness, and is thus a major, understudied target for modulating physiologic heterogeneity in sepsis.
First Authors:
Kale S Bongers
Correspondence Authors:
Robert P Dickson
All Authors:
Kale S Bongers,Rishi Chanderraj,Robert J Woods,Roderick A McDonald,Mark D Adame,Nicole R Falkowski,Christopher A Brown,Jennifer M Baker,Katherine M Winner,Daniel J Fergle,Kevin J Hinkle,Alexandra K Standke,Kimberly C Vendrov,Vincent B Young,Kathleen A Stringer,Michael W Sjoding,Robert P Dickson
评论
