Science：用工程菌治疗癌症（综述）
- ①细菌可在肿瘤中定植，用合成生物学工具可构建靶向肿瘤的治疗性工程菌；
- ②工程菌可特异性定位于肿瘤，通过分泌、扩散或细菌裂解机制，将携带的治疗性分子释放到肿瘤细胞内/外；
- ③工程菌还可通过自身成分（如LPS、鞭毛蛋白）和表达免疫相关分子（如肿瘤抗原、细胞因子）等，来重塑肿瘤微环境和免疫反应、招募适应性免疫细胞，以增强抗肿瘤免疫；
- ④工程菌还可与其他生物技术（如溶瘤病毒、合成菌群、CAR-T）和非生物技术（如MRI/PET成像、聚焦超声、纳米药物）联用，改善诊断和治疗。
主编推荐语
这是Science今天推出的细胞工程综述专刊中的一篇文章，总结了通过合成生物学方法构建的工程细菌在癌症治疗中的三大应用方向，包括与肿瘤细胞和免疫细胞互作，以及与其他疗法和技术的联合应用。推荐专业人士学习。
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Engineering bacteria as interactive cancer therapies
工程细菌作为互动式癌症治疗方法
10.1126/science.add9667
2022-11-24, Review
Abstract & Authors:展开
Abstract:收起
With increasing evidence that microbes colonize tumors, synthetic biology tools are being leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered systems can modulate the tumor microenvironment using a combination of their inherent immunogenicity and local payload production. Here, we review genetic circuits that enhance spatial and temporal control of therapeutic bacteria to improve their safety and efficacy. We describe the engineering of interactions among bacteria, tumor cells, and immune cells, and the progression from bacteria as single agents toward their rational combination with other modalities. Together, these efforts are building toward an emerging concept of engineering interactions between programmable medicines using synthetic biology.
First Authors:
Candice R Gurbatri
Correspondence Authors:
Tal Danino
All Authors:
Candice R Gurbatri,Nicholas Arpaia,Tal Danino
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