一文读懂早产儿肠道菌群影响因素（综述）
- ①检索筛选相关文献，最终纳入60篇研究数据；
- ②影响早产婴儿肠道菌群的因素包括年龄、分娩方式、抗生素使用及母乳等，证据强度较大；
- ③而种族、性别、强化剂使用、营养素及药物使用与婴儿肠道菌群的关联证据较少；
- ④肠道菌群中，包括双歧杆菌、葡萄球菌、肠球菌、拟杆菌、链球菌等，可能是肠道菌群改变的标志菌；
- ⑤早产儿可能同时受到诸多因素的影响，包括剖宫产、抗生素暴露、低出生体重、喂养方式等，其对婴儿肠道菌群的影响相对复杂。
主编推荐语
本文综合了现有证据，总结了早产儿肠道菌群的改变以及相关的影响因素，为进一步开展早产儿肠道菌群相关研究指明了方向，提供了基础。
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A systematic review of the factors influencing microbial colonization of the preterm infant gut
对影响早产儿肠道菌群定植因素的系统评价
10.1080/19490976.2021.1884514
2021-01-12, Review
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ABSTRACT
Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.
First Authors:
Miriam Aguilar-Lopez
Correspondence Authors:
Sharon M Donovan
All Authors:
Miriam Aguilar-Lopez,Andrew M Dinsmoor,Thao T B Ho,Sharon M Donovan
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