人口腔菌群中编码羊毛硫抗生素链球菌是肝脏疾病的潜在风险因子
- ①不同簇中的羊毛硫抗生素可能利用人体不同的生态位并影响人类健康；
- ②簇 A2 中的羊毛硫抗生素主要来自链球菌，在健康人群口腔菌群中丰度较高；
- ③变形链球菌产生的羊毛硫抗生素可能会扰乱肠道菌群并导致菌群失调；
- ④编码羊毛硫抗生素的两种链球菌菌株可能是导致肝脏疾病的病原体，来自链球菌属的羊毛硫抗生素对肝细胞有毒性作用；
- ⑤总之，编码簇 A2 羊毛硫抗生素的口服链球菌易位至肠道可能对人类健康产生不利影响并导致疾病。
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在这项研究中，作者进行了一项宏基因组关联研究，以分析羊毛硫抗生素与人类疾病之间的关系。研究表明A2 簇中编码羊毛硫抗生素的链球菌是肝脏疾病的潜在毒素，并且细菌从口腔转移到肠道可能对健康产生不利影响。作者表达了在下一步的研究中，需要使用小鼠模型进行验证，以证明羊毛硫抗生素对健康的影响。
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Lantibiotic-encoding Streptococcus in the human microbiome are underlying risk factors for liver diseases
人口腔菌群中的编码羊毛硫抗生素链球菌是肝脏疾病的潜在风险因子
10.1016/j.jinf.2022.02.020
2022-02-21, Article
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Recently, Streptococcus has been reported to be the etiology of several infectious diseases such as brain abscess and bacteremia in Journal of Infection.1,2 Here, we reported that Streptococcus sp. C150 and Streptococcus vestibularis, which encode lantibiotics, are potential risk factors for nonalcoholic fatty liver disease (NAFLD) and liver cirrhosis (LC), as revealed by a comparison of the gut microbiome of healthy subjects (n = 2042) and patients with diseases, including metabolic disorders, liver diseases, gastrointestinal diseases, and neurological disorders (n = 1683). We showed that the lantibiotic genes are frequently present and highly abundant in the gut microbiome of the patients with NAFLD and LC. Additionally, the deletion of these genes reduces toxicity to liver cells.
First Authors:
Baolei Jia,Kyung Hyun Kim
Correspondence Authors:
Baolei Jia,Che Ok Jeon
All Authors:
Baolei Jia,Kyung Hyun Kim,Wenting Ruan,Hyung Min Kim,Che Ok Jeon
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