配方奶粉中或许可降低蛋白摄入
- ①婴儿期摄入过多的蛋白可能会增加今后肥胖风险，所以研发一种修饰过的低蛋白奶粉（mLP）；
- ②健康足月儿随机分为3组，mLP组（1.7g蛋白/天），特殊配方奶粉组（2.1g蛋白/天）以及母乳喂养组；
- ③mLP组及配方奶粉组婴儿17周内体重增长量、体长、头围、腰围等指标及身体成分指标无统计学差异，不良事件发生率也无差异；
- ④mLP组儿童尿素含量低于配方奶粉组；
- ⑤与母乳喂养组相比，两组配方奶粉喂养的婴儿增长率、脂肪量、游离脂肪等指标均更高。
主编推荐语
有研究认为当下儿童肥胖率高的原因之一是配方奶粉的使用，使婴儿在生命早期摄入较多的蛋白质。本研究利用临床随机对照试验检验低蛋白的配方奶粉的安全性和作用。研究发现，低蛋白的奶粉一样能够给婴儿提供足够的营养。该研究提示未来的奶粉标准似乎可以降低对蛋白含量的要求。该举措或许可以降低儿童肥胖发生率。
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A modified low-protein infant formula supports adequate growth in healthy, term infants: a randomized, double-blind, equivalence trial
经修饰的低蛋白婴幼儿配方奶粉给健康足月儿提供足够的营养支持：一项随机双盲对照试验
10.1093/ajcn/nqz308
2019-12-23, Communication
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Background: A high protein intake in early life is associated with a risk of obesity later in life. The essential amino acid requirements of formula-fed infants have been reassessed recently, enabling a reduction in total protein content and thus in protein intake.
Objectives: We aimed to assess the safety of an infant formula with a modified amino acid profile and a modified low-protein (mLP) content in healthy term-born infants. Outcomes were compared with a specifically designed control (CTRL) infant formula.
Methods: In this double-blind, randomized controlled equivalence trial, infants received either mLP (1.7 g protein/100 kcal; n = 90) or CTRL formula (2.1 g protein/100 kcal; n = 88) from enrollment (age ≤ 45 d) to 6 mo of age. A breastfed group served as a reference (n = 67). Anthropometry and body composition were determined at baseline, 17 wk (including safety blood parameters), and 6 mo of age. The primary outcome was daily weight gain from enrollment up until the age of 17 wk (at an equivalence margin of ±3.0 g/d).
Results: Weight gain from baseline (mean ± SD age: 31 ± 9 d) up to the age of 17 wk was equivalent between the mLP and CTRL formula groups (27.9 and 28.8 g/d, respectively; difference: −0.86 g/d; 90% CI: −2.36, 0.63 g/d). No differences in other growth parameters, body composition, or in adverse events were observed. Urea was significantly lower in the mLP formula group than in the CTRL formula group (−0.74 mmol/L; 95% CI: −0.97, −0.51 mmol/L; P < 0.001). Growth rates, fat mass, fat-free mass, and several essential amino acids were significantly higher in both formula groups than in the breastfed reference group.
Conclusions: Feeding an infant formula with a modified amino acid profile and a lower protein content from an average age of 1 mo until the age of 6 mo is safe and supports an adequate growth, similar to that of infants consuming CTRL formula. This trial was registered at www.trialregister.nl as Trial NL4677.
First Authors:
Stefanie MP Kouwenhoven
Correspondence Authors:
Johannes B van Goudoever
All Authors:
Stefanie MP Kouwenhoven,Nadja Antl,Martijn JJ Finken,Jos WR Twisk,Eline M van der Beek,Marieke Abrahamse-Berkeveld,Bert JM van de Heijning,Henk Schierbeek,Lesca M Holdt,Johannes B van Goudoever,Berthold V Koletzko
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