Cell子刊：多途径的母婴菌群传递
- ①纳入120对母婴，分析出生30天内多个身体部位（母体6个、婴儿4个）菌群，评估不同部位菌群的母婴传递和早期发育；
- ②58.5%的婴儿菌群源自母体（母乳菌群贡献最大），母体所有部位的菌群都为婴儿多个部位的菌群提供种子；
- ③分娩和喂养方式是塑造婴儿不同部位菌群的共同因素，其他因素（如有无兄弟姐妹）则影响婴儿特定部位菌群；
- ④相较于阴道分娩，剖腹产使母婴间的粪便菌群转移减少，但可被其他部位的菌群补偿（母乳菌群的贡献增大）。
主编推荐语
生命早期的菌群定植可以影响孩子未来的健康。Cell Host and Microbe发表的一项最新研究中，来自荷兰的研究者通过分析母亲和婴儿的多个身体部位（生态位）的菌群组成，揭示了母婴菌群播种的复杂性。该研究表明，母体对婴儿菌群的贡献因生态位而异，母乳菌群的作用尤为明显。此外，该研究证实了"辅助"播种途径的存在，当播种模式被扰乱时（如剖腹产中母婴肠道微生物播种减少），辅助途径（如母乳）可以起到部分补偿作用，即母亲能够通过替代的补偿途径将微生物传递给婴儿。
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Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites
跨越多个身体部位的母亲到婴儿的菌群传递及婴儿菌群发育
10.1016/j.chom.2023.01.018
03-08, Article
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Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.
First Authors:
Debby Bogaert
Correspondence Authors:
Debby Bogaert,Wouter AA de Steenhuijsen Piters
All Authors:
Debby Bogaert,Gina J van Beveren,Emma M de Koff,Paula Lusarreta Parga,Carlos E Balcazar Lopez,Lilian Koppensteiner,Melanie Clerc,Raiza Hasrat,Kayleigh Arp,Mei Ling JN Chu,Pieter CM de Groot,Elisabeth AM Sanders,Marlies A van Houten,Wouter AA de Steenhuijsen Piters
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