国内团队：肠道菌群失调与血清尿酸升高有关
- ①发现队列包含1392名农村参与者，平均61.3岁，女性占57.4%，高尿酸血症占17.2%；
- ②与正常尿酸者相比，高尿酸血症患者的肠道菌群丰富度和多样性降低，菌群组成发生改变，粪球菌属相对丰度降低，京都基因与基因组百科全书（KEGG）代谢通路分析发现组间菌群的氨基酸和核苷酸代谢通路存在显著差异；
- ③肠道菌群丰富度和多样性改变，以及粪球菌属相对丰度较低也与高水平的血清尿酸有关；
- ④这些发现在480名参与者的验证队列中得到了重复。
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近期中南大学湘雅医院雷光华和曾超作为共同通讯在Arthritis and Rheumatology发表了一项研究成果，在对中国农村居民进行的一项研究（称为“发现队列”）中，发现肠道菌群失调与血清尿酸水平升高有关，这在另一项针对中国城市居民的研究（称为“验证队列”）中得到验证，研究结果提示肠道微生态失调可能参与调节血清尿酸水平。
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Association between gut microbiota and elevated serum urate in two independent cohorts
两个独立队列肠道微生物群与血清尿酸水平升高的关系
10.1002/art.42009
2021-11-01, Article
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OBJECTIVES: Hyperuricemia is a precursor to gout and is often present in other metabolic diseases that are promoted by microbiome dysbiosis; however, no study has examined the association of gut microbiota with hyperuricemia and serum urate in humans.
METHODS: Study participants were derived from a community-based observational study, the Xiangya Osteoarthritis Study (discovery cohort). Hyperuricemia was defined as the presence of serum urate level >357 μmol/L for women and >416 μmol/L for men. Gut microbiota was analyzed using 16S rRNA sequencing from stool samples. We examined the relation of microbiota dysbiosis (i.e., richness, diversity, composition, and relative abundance of microbiota taxa) and predicted functional pathways to prevalent hyperuricemia and serum urate levels. We verified the associations in an independent observational study, the Step Study (validation cohort).
RESULTS: The discovery cohort consisted of 1,392 rural participants (mean age: 61.3 years; women: 57.4%; hyperuricemia: 17.2%). Participants with hyperuricemia had decreased richness and diversity, altered composition of microbiota, and lower relative abundances of genus Coprococcus compared with those with normouricemia. Predicted Kyoto Encyclopedia of Genes and Genomes metabolism pathways belonged to amino acid and nucleotide metabolisms were significantly altered in individuals with hyperuricemia compared with those with normouricemia. Gut microbiota richness, diversity and low relative abundances of genus Coprococcus were also associated with high levels of serum urate. These findings were replicated in the validation cohort with 480 participants.
CONCLUSIONS: Gut microbiota dysbiosis was associated with elevated serum urate levels. Our study raises the possibility that microbiota dysbiosis may modulate serum urate levels.
First Authors:
Jie Wei
Correspondence Authors:
Chao Zeng,Guanghua Lei
All Authors:
Jie Wei,Yuqing Zhang,Nicola Dalbeth,Robert Terkeltaub,Tuo Yang,Yilun Wang,Zidan Yang,Jiatian Li,Ziying Wu,Chao Zeng,Guanghua Lei
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