中山大学：菌群在IBD中的作用（综述）
- ①IBD患者肠道中特定细菌（柔嫩梭菌群、Roseburia菌属、Akk菌等）及细菌产物（SCFA、色氨酸衍生物、次级胆汁酸、多糖A等）减少，这些因素可能在IBD中起保护性作用；
- ②特定细菌（粘附侵袭性大肠杆菌、屎肠球菌、产肠毒素脆弱拟杆菌、简明弯曲菌等）及牛磺酸等菌群代谢产物在IBD患者的肠道中富集，可能促进IBD的发生发展；
- ③肠道真菌、病毒的失调也可能促进IBD；
- ④益生菌/元、后生元、噬菌体、粪菌移植等靶向菌群的治疗方式或可治疗IBD。
主编推荐语
肠道菌群失调与炎症性肠病（IBD）的因果关联尚未被完全证实，但许多研究发现，至少部分菌群变化是IBD的起因或在IBD中起保护性作用。中山大学附属第六医院的牟相宇、兰平与团队在Protein & Cell上发表的一篇综述文章，详细介绍了在IBD中起到潜在保护性作用的细菌物种、细菌产物及相关通路，以及可能促进IBD发生发展的细菌物种、细菌产物及相关通路，同时总结了IBD相关的肠道真菌及病毒变化，最后讨论了通过调控菌群治疗IBD的潜在可能。
关键字
延伸阅读本研究的原文信息和链接出处，以及相关解读和评论文章。欢迎读者朋友们推荐！
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy
IBD中的菌群：从发病机制到治疗
10.1007/s13238-020-00745-3
2020-06-29, Review
Abstract & Authors:展开
Abstract:收起
Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence worldwide in the 21st century while its accurate etiology remains unclear. In the past decade, gut microbiota dysbiosis has consistently been associated with IBD. Although many IBD-associated dysbiosis have not been proven to be a cause or an effect of IBD, it is often hypothesized that at least some of alteration in microbiome is protective or causative. In this article, we selectively reviewed the hypothesis supported by both association studies in human and pathogenesis studies in biological models. Specifically, we reviewed the potential protective bacterial pathways and species against IBD, as well as the potential causative bacterial pathways and species of IBD. We also reviewed the potential roles of some members of mycobiome and virome in IBD. Lastly, we covered the current status of therapeutic approaches targeting microbiome, which is a promising strategy to alleviate and cure this inflammatory disease.
First Authors:
Sheng Liu
Correspondence Authors:
Ping Lan,Xiangyu Mou
All Authors:
Sheng Liu,Wenjing Zhao,Ping Lan,Xiangyu Mou
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